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Effect of flaxseed consumption on flow-mediated dilation and inflammatory biomarkers in patients with coronary artery disease: a randomized controlled trial. Suzuki R, Rylander-Rudqvist T, Saji S, et al. All rights reserved. Certain antibioticsspecifically quinolone antibiotics (like Cipro) and tetracycline antibiotics (like Achromycin and Sumycin)interact with zinc in the gastrointestinal tract and don't allow the. Consult with a licensed healthcare professional before using any herbal/health supplement. Plasma enterolignan concentrations and colorectal cancer risk in a nested case-control study. Flaxseed is often mixed with foods and used in baked goods, such as muffins, breads, and snack bars. Flaxseed might also be helpful for managing diabetes and lowering the risk of heart disease. View abstract. The omega-3 supplement may increase your fasting blood sugar levels and decrease the effectiveness of your diabetes medication. View abstract. View abstract. 2013 Aug 1;167(8):708-13. J Nutr 2008;138:938-45. View abstract. View abstract. Anaphylaxis caused by flaxseed. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. View abstract. Cancer Epidemiol Biomarkers Prev 2006;15:1132-6. There is a problem with Fact Checked by Paul Bossung. Ann N Y Acad Sci 1990;595:281-90. The authors of the article in the Journal of Food Science and Technology call flaxseed oil a functional food because of its potential health benefits. This means multiple trips to the bathroom to alleviate bloating, stomach pain, constipation, diarrhea, and the like. Sun J, Bai H, Ma J, et al. It may take 1 to 3 days before this medication starts working. Sorry, we have no data available. JAMA 2005;294:1493-1504. You should see your doctor immediately if you suspect youre having a reaction from the intake of flaxseed oil. View abstract. Generic name: flax (FLACKS) This content does not have an English version. Before using flax, talk to your healthcare provider. Am J Clin Nutr 1994;60:122-8. This means that flaxseed can help improve digestion and lower cholesterol levels, while flaxseed oil does not have these effects. Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, Ruffin MT, Moul JW, Brenner DE, Demark-Wahnefried W. Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer. Giovannucci E, Rimm EB, Colditz GA, et al. For this reason, it is critical to discuss possible interactions with Trulicity before you start treatment with it. OTHER NAME(S): Alasi, Aliviraaii, Brown Flaxseed, Brown-Seeded Fl, Flax (Linum usitatissimum) is a food and fiber crop. Hypertension. View abstract. Therefore, the quality and contents of flaxseed oil arent regulated and standardized. Do not take this medication for more than 7 days unless directed by your doctor. Asia Pac J Clin Nutr. View abstract. J Res Med Sci. Bierenbaum ML, Reichstein R, Watkins TR. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Cancer Epidemiol Biomarkers Prev 2008;17:3241-51. View abstract. Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. Clin Cancer Res 2004;10:7703-11. Yari Z, Rahimlou M, Eslamparast T, Ebrahimi-Daryani N, Poustchi H, Hekmatdoost A. Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study. Do not take flax without medical advice if you are using any of the following medications: any medications for diabetes or high blood pressure; This list is not complete. Nutr Rev 2004;62:18-27. View abstract. The evidence is mixed as to whether flaxseed or flaxseed oil has any effect on the prostate or the risk of prostate cancer. Mohammadi-Sartang M, Sohrabi Z, Barati-Bodaji R, Raeisi-Dehkordi H, Mazloom Z. Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials. Most of the animal studies have focused on breast cancer. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. View abstract. J Am Coll Nutr 2008;27:65-74. Fish, walnuts, chia seeds and flaxseed oil are excellent sources of omega-3 fats. The omega-3 fatty acids in flaxseed meal by interact negatively with blood-thinning medications. 2018 Feb 1;76(2):125-39. Oncology Nutrition advises that you should discuss the use of flax seeds with your doctor and avoid the use of flaxseed oil altogether because it provides no benefit to those with prostate cancer. Can Apoaequorin Really Improve Your Memory? Wong H, Chahal N, Manlhiot C, Niedra E, McCrindle BW. View abstract. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Flaxseed oil. Flaxseed: a potential treatment for lupus nephritis. If we combine this information with your protected The side effects of flaxseed oil may lead to adverse reactions if you consume it and take certain medications or have particular medical conditions. Role of Plant-Derived Omega-3 Fatty Acids in Human Nutrition. All rights reserved. Haghighatsiar N, Askari G, Saraf-Bank S, Feizi A, Keshmiri H. Effect of flaxseed powder on cardiovascular risk factor in dyslipidemic and hypertensive patients. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Flaxseed oil, the most commonly used high risk supplement that contains phosphorus, was taken by 16 percent of patients with normal or mildly reduced kidney function. View abstract. J Clin Endocrinol Metab 2002;87:1527-32.. View abstract. The Problem With Flaxseed And Thyroid Function. Leitzmann MF, Stampfer MJ, Michaud DS, et al. There is some concern that it might interfere with the body's ability to absorb medications taken by mouth because it might sweep them out of the digestive tract too quickly. Using different formulations together increases the risk of an overdose. You may opt-out of email communications at any time by clicking on Fatty acids and lignans in unground whole flaxseed and sesame seed are bioavailable but have minimal antioxidant and lipid-lowering effects in postmenopausal women. J Am Coll Nutr 2010;29(1):72-80. View abstract. It may take 1 to 3 days before this medication starts working. You should also be cautious about consuming flaxseed oil if you use medications that alter your blood sugar levels. 2016 Jun;35(3):615-25. View abstract. One tablespoon of flaxseed oil has 7.26 grams. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyperplasia. Nutritional attributes of traditional flaxseed in healthy young adults. ", Kardiologia Polska: "Linseed Oil Increases HDL3 Cholesterol and Decreases Blood Pressure in Patients Diagnosed With Mild Hypercholesterolaemia", Phytotherapy Research: "A Comparison Between the Effects of Flaxseed Oil and Fish Oil Supplementation on Cardiovascular Health in Type 2 Diabetic Patients With Coronary Heart Disease: A Randomized, Double-Blinded, Placebo-Controlled Trial", U.S. National Library of Medicine: "Warfarin". Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Taking flaxseed by mouth may help reduce. Consult your doctor before relying on flaxseed oil to boost your omega-3 fatty acid levels to ensure youre using the supplement safely. Mousavi Y, Adlercreutz H. Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. You need to be careful in using these supplements if you have diabetes or any other condition that affects your blood sugar levels. Carcinogenesis 1996;17:1373-6. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. This includes angelica (dong quai), capsicum, clove, danshen, garlic, ginger, ginkgo, horse chestnut, panax ginseng, poplar, red clover, saw palmetto, turmeric, and willow. Verheus M, van Gils CH, Keinan-Boker L, et al. 2019;46:36-43. Taking flaxseed along with medications that also slow blood clotting might increase the risk of bruising and bleeding. Accessed Sept. 27, 2017. Flaxseed and cardiovascular risk. Touillaud MS, Thiebaut AC, Fournier A, et al. Because of the potential for flaxseed oil side effects and drug interactions, you should talk to your primary care provider before regularly supplementing your diet with the plant oil. To be as proactive as possible, consult your doctor about using flaxseed oil as a dietary supplement before you begin to use it. View abstract. Medically reviewed by Drugs.com on Jul 25, 2022. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023 . These types of drugs, herbs and supplements reduce blood clotting. Dietary phytoestrogen intake is associated with reduced colorectal cancer risk. National Institutes of Health: Office of Dietary Supplements: "Omega-3 Fatty Acids", Journal of Food Science and Technology: "Flax and Flaxseed Oil: An Ancient Medicine & Modern Functional Food", Harvard T.H. View abstract. A total of 12 drugs are known to interact with green tea. Flaxseed oil may be a good option for you. 2019;97(6):557-561. Flaxseed oil may cause complications with women who are pregnant because of its ability to affect hormones. Reprod Toxicol 2007;23:397-406. However, it requires a steady dose of essential nutrients, which must come from food or supplements, in order to function at its best. 2020;29(1):61-67. Phase II Trial of Flaxseed to Prevent Acute Complications After Chemoradiation for Lung Cancer. Though flaxseed oil benefits your blood pressure, if you take blood pressure medication and supplement your diet regularly with flaxseed oil, the combination may lower your blood pressure too much. Bloedon LT, Szapary PO. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Finnegan YE, Minihane AM, Leigh-Firbank EC, et al. J Med Food 2012;15:840-5. Nitrates, such as nitroglycerin (Nitrostat, Nitro-Dur, others) and isosorbide (Isordil, Bidil) Digoxin Licorice The herb licorice may lower warfarin levels and can add to digoxin's effects. Flax can affect blood-clotting and may increase your risk of bleeding. Some people also take flaxseed to treat inflammatory diseases. View abstract. To help you remember, take it at the same time(s) each day. Raspberries - joint pain. Flaxseed in pediatric hyperlipidemia: a placebo-controlled, blinded, randomized clinical trial of dietary flaxseed supplementation for children and adolescents with hypercholesterolemia. View abstract. Bodybuilder Darwin Uribe Will Withdraw From 2023 Arnold Classic. Menopause 2012;19:48-53. Occasionally, using flaxseed or flaxseed oil causes an allergic reaction. This means that flaxseed can help improve digestion and lower cholesterol levels, while flaxseed oil does not have these effects. Answer: Atorvastatin (Lipitor), rosuvastatin (Crestor), and other cholesterol-lowering statin drugs can be affected by taking supplements and can affect your ability to absorb certain vitamins and minerals. Arjmandi BH. Appetite 2012;58:490-5. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. See if Ritual products are right, It's no secret that vitamins can improve your health, but not all vitamins and minerals are created equal. Flaxseed is high in soluble fiber and in lignans, which contain phytoestrogens. Even though it's just a food, flaxseed oil may not mix well with certain health conditions or medications. A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults. We avoid using tertiary references. Furthermore, some blood thinners, NSAID pain killers, hormone treatments, and certain medications for blood pressure, cholesterol, and diabetes may interact with flaxseed oil and flaxseed. Plasma enterolignans are associated with lower colorectal adenoma risk. Nesbitt PD, Lam Y, Thompson LU. Cockerell KM, Watkins AS, Reeves LB, et al. View abstract. Anticoagulant and anti-platelet drugs, herbs and supplements. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause. Omega 3 dietary sources include flax seeds, chia seeds, walnuts, and fish. J Steroid Biochem Mol Biol 1994;50:205-12.. View abstract. To provide you with the most relevant and helpful information, and understand which Dietary lignans and postmenopausal breast cancer risk by oestrogen receptor status: a prospective cohort study of Swedish women. Mandasescu S, Mocanu V, Dascalita AM, et al. Walnuts - bone loss, joint pain. You may be eager to find a supplement to boost the omega-3 fatty acids in your body. those that alter your blood flow and bleeding, including: some nonsteroidal anti-inflammatory drugs, like ibuprofen and naproxen. Mayo Clinic does not endorse any of the third party products and services advertised. DOI: What are omega-3 fatty acids from fish oil? You can find flaxseed oil in oil form, in capsules, or even in enriched food products. Nutr Rev. Prasad K, Mantha SV, Muir AD, Westcott ND. Khalesi S, Irwin C, Schubert M. Flaxseed consumption may reduce blood pressure: a systematic review and meta-analysis of controlled trials. 2013 Dec;62(6):1081-9. Similar to any other medication, Trulicity (dulaglutide) may interact with certain drugs or health conditions. J Med Food. View abstract. Other uses not proven with research have included enlarged prostate, heart disease, constipation, high blood pressure, irritable bowel syndrome, menopausal symptoms, weight loss, diverticulitis, attention deficit-hyperactivity disorder (ADHD), cancer (prostate, breast, lung, endometrial), and others. You should consume water regularly if you use flax seeds as a supplement. Flaxseed might make these estrogen-containing drugs less effective. Am J Clin Nutr 2006;84:400-5. Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women. 2005 - 2023 WebMD LLC. Cotterchio M, Boucher BA, Manno M, et al. 2016 Feb;25:90-5. In addition, 1.3 percent of patients who were unaware they had moderate kidney impairment took flaxseed oil, which translates to 167,500 Americans. Low adherence may be a contributing factor leading to uncontrolled blood pressure in patients. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It is not known whether flax passes into breast milk or if it could harm a nursing baby. Lucas EA, Wild RD, Hammond LJ, et al. View abstract. Schabath MB, Hernandez LM, Wu X, et al. View abstract. View abstract. Flaxseed oil doesn't have these phytoestrogens. You should use these products with caution. Lancet 1982;2:1295-9. View abstract. Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients. Skip the missed dose if it is almost time for your next scheduled dose. Thompson LU, Rickard SE, Cheung F, et al. Although not all side effects are known, flax is thought to be likely safe for most people when taken by mouth. Flaxseeds are high in potassium. Flaxseed is considered to be a goitrogen. Ann Nutr Metab 2000;44:263-5. Beta . Nutr Cancer 1999;33:188-95. J Nutr. Zhang W, Wang X, Liu Y, et al. Sairanen U, Piirainen L, Nevala R, Korpela R. Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the severity of mild constipation in elderly subjects. the unsubscribe link in the e-mail. View abstract. View abstract. View abstract. Bongartz U, Hochmann U, Grube B, et al. Koizumi Y, Arai H, Nagase H, Kano S, Tachizawa N, Sagawa T, Yamaguchi M, Ohta K. [Case report: anaphylaxis caused by linseed included in baked bread]. Cunnane SC, Hamadeh MJ, Liede AC, et al. Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial. Mirghafourvand M, Mohammad-Alizadeh-Charandabi S, Ahmadpour P, Javadzadeh Y. Dietary phytoestrogen intake--lignans and isoflavones--and breast cancer risk (Canada). Clin Cancer Res 2005;11:3828-35. However, when taken in large amounts and with too little water, flaxseed can cause: Avoid use of flaxseed and flaxseed oil during pregnancy. 016 Sep 1;21:70. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Chan School of Public Health. Am J Clin Nutr 2004;79:318-25.. View abstract. Int J Cancer 2004;111:444-50.. View abstract. View abstract. Information from this source is evidence-based and objective, and without commercial influence. Things to remember when you fill your prescription. View abstract. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. 1. Hailshadow/Getty Images. Wang C, Makela T, Hase T, et al. Furthermore, some thyroid medications can interfere with vitamin D absorption or metabolism, resulting in low vitamin D levels. J Diet Suppl 2011;8:257-65. Dietary flaxseed enhances the inhibitory effect of tamoxifen on the growth of estrogen-dependent human breast cancer (mcf-7) in nude mice. What medications does flaxseed interfere with? de Deckere EAM, Korver O, Verschuren PM, Katan MB. Aitken-Saavedra J, Chaves Tarquinio SB, De Oliveira da Rosa WL, et al. Learn about the medical uses, claims, and side effects of flaxseed. There are three primary types of omega-3s, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. Kilkkinen A, Stumpf K, Pietinen P, et al. Ultimately, if flaxseed is to blame, an upped dosage of levothyroxine medication is probably needed going further. Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen. Drink plenty of water each day while you are taking this product. View abstract. The relatively few animal studies addressing other cancers have shown some . Flaxseed oil doesnt contain fiber like flax seeds, however. There are many studies currently under way to link the use of flaxseed oil with positive health benefits, but there is no standard use of the supplement. Exp Biol Med (Maywood) 2007;232:1071-80. J Med Food 2008;11:207-14. Breast Cancer Res Treat 2000;64:49. Advertising revenue supports our not-for-profit mission. Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women. Avoid using flax together with other herbal/health supplements that can lower blood sugar, such as alpha-lipoic acid, chromium, devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ginseng, and others. View abstract. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Mammalian lignans inhibit the growth of estrogen-independent human colon tumor cells. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. (n.d.). The effect of flaxseed supplementation on the initiation and promotional stages of mammary tumorigenesis. Effects of Vitex agnus and flaxseed on cyclic mastalgia: a randomized controlled trial. Talk to your primary care provider or pharmacist to discuss flaxseed oil drug interactions. Use this medication regularly to get the most benefit from it. Research on the use of flaxseed and flaxseed oil for specific conditions shows: When used in combination with daily exercise and a low cholesterol diet, flaxseed might help control cholesterol levels. View abstract. Chen J, Hui E, Ip T, Thompson LU. The grapefruit causes larger amounts of the medication to stay in your body for a longer period of time, explains Mayo Clinic nutritionist Katherine Zeratsky 3. Kuijsten A, Arts IC, Hollman PC, et al. Accessed Sept. 27, 2017. Alonso L, Marcos ML, Blanco JG, et al. Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials. There is a chance you may have an allergy to flax seeds and flaxseed oil. Learn about the medical uses, claims, and side effects of flaxseed. Leon F, Rodriguez M, Cuevas M. Anaphylaxis to Linum. Menopause 2006;13:631-42. Here are the 15 best vitamin brands to help. Urology 2001;58:47-52. Learn how we can help 3.9k views Reviewed >2 years ago Thank Dr. John Munshower and 4 doctors agree 1 thank Flaxseed is a good source of dietary fiber. Haggans CJ, Hutchins AM, Olson BA, et al. These shiny seeds are packed with other nutrients, too,. View abstract. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Clin Nutr. Flaxseed supplementation in hyperlipidemic patients. Review/update the What Are the Benefits of Flaxseed Oil Pills? Yari Z, Cheraghpour M, Hekmatdoost A. Flaxseed and/or hesperidin supplementation in metabolic syndrome: an open-labeled randomized controlled trial. other information we have about you. Flaxseeds are a good source of. Alvarez-Perea A, Alzate -Prez D, Doleo Maldonado A, Baeza ML. Flaxseed oil contains ALA, which your body primarily uses as a source of energy, according to Harvard T.H. Dietary fiber and breast cancer. Your body is an amazing physiological machine. Eur J Clin Nutr 1998;52:749-53. Clin Nutr ESPEN. Estrogens. Flax is the seed of a plant called Linum usitatissimum, and is also known as Flax Seed, Alasi, Aliviraaii, Brown Flaxseed, Brown-Seeded Flax, Echter Lein, Flachssamen, Flax Hull, Flax Lignans, Gemeiner Flachs, Graine de Lin, Kattan, Keten, Leinsamen, Lignans, Lin, Olagineux, Lin Textile, Linaza, Lini Semen, Linho, Lino, Linseed, Lint Bells, But it can interfere with the absorption of some medications and supplements.Take oral agents one hour before -- or two hours after -- flaxseed to prevent decreased absorption. View abstract. It is created by eHealthMe based on reports of 563 people who take Flaxseed and . It is not certain whether flax is effective in treating any medical condition. View abstract. Arerugi. information submitted for this request. It can: Ground flax seed is a rich source of the essential fatty acid alpha-linolenic acid (ala), which is a biologic precursor to omega-3 fatty acids. Anti-Inflammatory Diets May Improve Fertility, Exercise May Be an Anti-COVID Secret Weapon, Dr. Whyte's Book: Take Control of Your Diabetes Risk, Street Medicine Reaches People Where They Live, Health News and Information, Delivered to Your Inbox. The phase IV clinical study analyzes what interactions people who take Flaxseed and Anastrozole have. It might compete with drugs that contain estrogen. View abstract. Fish oil may be a better and safer choice. View abstract. A prospective study of dietary fat and risk of prostate cancer. Barre DE, et al. View abstract. Discuss with your doctor the benefits of flaxseed oil for your health before trying it out. Often youll need to take flaxseed oil a few hours before administering medications to make sure your body absorbs them properly. Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. View abstract. J Steroid Biochem Mol Biol 1992;41:615-9.. View abstract. Flaxseed - More Interactions. Taking flaxseed by mouth seems to help reduce, Breast pain (mastalgia). Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Not all possible interactions are listed in this product guide. Flaxseed oil might lower blood pressure. Pan A, Sun J, Chen Y, et al. Some people use black seed oil supplements to treat certain health conditions, including arthritis, allergies, asthma, and diabetes, and maintain a healthy weight. Flaxseed oil is available in liquid and capsule form. Consumption of a flaxseed-rich food is not more effective than a placebo in alleviating the climacteric symptoms of postmenopausal women. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Read more: 17 Reasons Why You Probably Need More Omega-3s in Your Diet. . Flaxseed might lower blood pressure. Dietary flaxseed interaction with tamoxifen induced tumor regression in athymic mice with MCF-7 xenografts by downregulating the expression of estrogen related gene products and signal transduction pathways. View abstract. Nutr Metab (Lond) 2021;18(1):91. 2014;22:43. J Am Coll Nutr 1993;12:501-4. Saw palmetto Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: Aspirin Clopidogrel Warfarin St. John's wort Effect of a homemade salivary substitute prepared using chamomile (Matricaria chamomilla L.) flower and flax (Linum usitatissimum L.) seed to relieve primary burning mouth syndrome: a preliminary report. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Zeleniuch-Jacquotte A, Lundin E, Micheli A, et al. Clin Rheumatol. Refrigerated flaxseed should be used within 30 days of being ground, and frozen flaxseed should be used within 45 days of storing. Rose DP. Kuijsten A, Hollman PC, Boshuizen HC, et al. Examples of barbiturates and medications that have barbiturate actions include: Felbatol (felbamate) View abstract. These blood-thinners are broken down in the body by the liver enzyme CYP3A4. Br J Nutr. Does Flaxseed Interact with other Medications? Eur.J Clin.Nutr. Flaxseed reduces some risk factors of cardiovascular disease. This will help prevent any negative reactions that might arise. However, you should always talk to your primary care provider to discuss flaxseed oil dosage and safety before adding the plant oil to your daily routine. When considering the use of herbal supplements, seek the advice of your doctor. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Flaxseed oil as a dietary supplement is not regulated by the U.S. Food and Drug Administration. Use caution when adding flaxseed oil to your diet or using it as a supplement. But what you might not realize is that flaxseed contains very large amounts of lignans and phytoestrogens, making it one of the most estrogenic foods around.