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information and will only use or disclose that information as set forth in our notice of Diabetes treatment: Can cinnamon lower blood sugar? You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Prescription and OTC Aspirin relieves pain and inflammation and helps to thin the blood. The dose is according to the body weight and severity of the condition. Natural Medicines. This list covers only some interactions. Talk to your pharmacist for more details. It will give you more information about nitrate medicines, and it will also provide you with a full list of side-effects which you could experience from taking isosorbide mononitrate. Isosorbide (C6H10O4), also called D-Isosorbide dinitrate, is a bio-product sourced from starch. The Swedish Multicentre Group. A randomized, double-blind, cross-over study. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Nitroglycerin has an average rating of 1996 Dec;3(12):802-806. doi: 10.1097/00045391-199612000-00003. Your doctor will tell you which is the right dose for you, and this will also be printed on the label of the pack to remind you about what the doctor said to you. Real test is coronary angiography. Canada residents can call a provincial poison control center. This content does not have an English version. You may report side effects to the FDA at 1-800-FDA-1088. It is important that you follow the instructions your doctor gives to you about when to take your doses. Properly discard this product when it is expired or no longer needed. If headaches continue or become severe, tell your doctor promptly. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. ask your doctor about the safe use of alcoholic beverages while you are taking isosorbide. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. information highlighted below and resubmit the form. Older adults may be more sensitive to the side effects of this medication, especially dizziness and lightheadedness, which could increase the risk of falls. The .gov means its official. https://naturalmedicines.therapeuticresearch.com. We don't support your browser. It has a very short duration of action and may not be suitable for some people. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Each day, take the first dose when you wake up, then take the second dose 7 hours later. Patient is a UK registered trade mark. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. Along with its needed effects, a medicine may cause some unwanted effects. Should I avoid certain foods while taking Isosorbide Mononitrate? 45, Migranal), ergoloid mesylates (Hydergine), ergotamine (in Cafergot, in Migergot), methylergonovine (Methergine), methysergide (Sansert; no longer available in the U.S.), and pergolide (Permax; no longer available in the U.S.); medications for high blood pressure, heart failure, or an irregular heartbeat. Unable to load your collection due to an error, Unable to load your delegates due to an error. Tachjian A, et al. To avoid this problem, get up slowly, resting your feet on the floor for a few minutes before standing up. If you have any problems with the way your liver works, or any problems with the way your kidneys work. Take the missed dose as soon as you remember it. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. To view a report comparing 3 (or more) medications, please sign in or create an account. If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice. View more, Nitroglycerin dilates veins, relieving chest pain and lowering blood pressure. Things to remember when you fill your prescription. The extended-release tablet usually is taken once daily in the morning. Severe postural hypotension with light-headedness and dizziness is frequently observed after the consumption of alcohol. Take your next dose at the regular time. Some of the common derivatives include isosorbide dinitrate and isosorbide mononitrate, which are . Licorice. Some people feel dizzy or fall when changing positions, such as going from sitting to standing. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Do not take two doses together to make up for a missed dose. In the US - Call your doctor for medical advice about side effects. Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: It's not suggested to take St. John's wort if you take blood thinners. Please see a good cardiologist, get admitted, get checked thoroughly. Commonly reported side effects include: See also: isosorbide mononitrate side effects in more detail. This chest pain can feel more intense or painful than it was before you began taking isosorbide mononitrate (Monoket). "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Zhonghua Yi Xue Za Zhi (Taipei). Take extra precautions to avoid falling during your treatment with isosorbide. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less commonAcid or sour stomachanxietyback painbelchingblemishes on the skinbloatedbreast painburning feeling in the chest or stomachburning, dry, or itching eyeschange in color visionchanges in visioncold sweatscongestionconstipationcontinuing ringing or buzzing or other unexplained noise in the earscough producing mucusdecreased interest in sexual intercoursedifficulty seeing at nightdifficulty with movingdischarge, excessive tearingdouble visiondrooping upper eyelidsdull ache or feeling of pressure or heaviness in the legsearacheexcess air or gas in the stomach or intestinesfeeling of constant movement of self or surroundingsfeeling of warmthfeeling unusually coldfrequent urge to defecatefrozen shoulderfull feelinghearing lossheartburnhyperventilationinability to have or keep an erectionincreased appetiteincreased sensitivity of the eyes to sunlightincreased sputumindigestionirritabilityitching skin near damaged veinslack or loss of strengthloss in sexual ability, desire, drive, or performancemuscle or bone painmuscle stiffness or weaknessnightmaresnoisy breathingpain or tenderness around the eyes and cheekbonespassing gaspimplespoor concentrationrashredness of the face, neck, arms, and occasionally, upper chestredness, pain, swelling of the eye, eyelid, or inner lining of the eyelidredness, swelling, or soreness of the tonguerestlessnessseeing doublesensation of spinningsleepiness or unusual drowsinesssmall clicking, bubbling, or rattling sounds in the lung when listening with a stethoscopesmall lumps under the skinsore mouth or tonguestiff neckstomach bloating, burning, cramping, or painstomach discomfort or upsetstraining while passing stoolstuffy nosesudden sweatingswollen feet and anklestender, swollen glands in the necktenderness in the stomach areaterrifying dreams causing sleep disturbancestooth disordertrouble swallowinguncontrolled twisting movements of the neckvoice changesweight losswhite patches in the mouth, tongue, or throatOther side effects not listed may also occur in some patients. What are the interactions of Isosorbide Mononitrate ? Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. Your dose may need to be gradually decreased. Elsevier; 2021. https://www.clinicalkey.com. Results: Reduction of blood-nitrate concentrations to low levels for 4 to 12 hours each day usually maintains effectiveness in such patients. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Are you looking for information on isosorbide dinitrate (Isordil) instead? Many common herbal supplements interact with common heart medicines. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. It does not have such side effects. Herbal supplements can strongly affect the body. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Heres what you need to know about alcohol and blood pressure including how alcohol can interact with your blood pressure medications. URL of this page: https://medlineplus.gov/druginfo/meds/a682348.html. https://naturalmedicines.therapeuticresearch.com. Eur Heart J. It's usually not a problem for most people unless you drink alcohol or take other medications that can also lower your blood pressure. Try to keep your regular appointments with your doctor. McGraw Hill; 2022. https://accessmedicine.mhmedical.com/search. Does isosorbide mononitrate (Monoket) affect your kidneys? Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study. Headaches can be a sign that the medicine is working, and they might lessen with continued use of the medication. Keep all medications away from children and pets. Classes: Nitrates, Angina Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths tablet 10mg 20mg. . To provide you with the most relevant and helpful information, and understand which Use this medication regularly to get the most benefit from it. During pregnancy, this medication should be used only when clearly needed. Isosorbide mononitrate: isosorbide mononitrate. Natural Medicines. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Keep all medicines out of the reach and sight of children. This medicine is for you. Store at room temperature away from light and moisture. Natural Medicines. Some brands of isosorbide mononitrate tablets should be taken two or three times a day. It also relaxes and widens blood vessels in your heart (coronary arteries) which increases the flow of blood to your heart muscle. The table below contains some of the most common ones associated with isosorbide mononitrate. When used regularly on a long-term basis, this helps prevent angina attacks from occurring. Murray MT. These side effects may go away during treatment as your body adjusts to the medicine. Does Isosorbide Mononitrate interact with other drugs you are taking? If your chest pain attacks happen more often, last longer, or become more severe at any time during your treatment, call your doctor. Isosorbide-2,5-dinitrate and isosorbide-5-mononitrate, the low-potent organic nitrates, are directly metabolized in the endoplasmic reticulum of the vascular smooth muscle cells via cytochrome P450 enzymes, resulting in direct production of nitric oxide (Mnzel et al., 2005).In contrast, the highly potent organic nitrates such as glyceryl trinitrate (GTN) and pentaerythritile tetranitrate . Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. Herbal supplements and heart medicines may not mix, Your blood pressure, if you also take a drug to treat high blood pressure, Beta blockers, such as atenolol (Tenormin), nadolol (Corgard) or propranolol (Inderal LA, Innopran XL), Calcium channel blockers, such as diltiazem, nifedipine (Procardia) and verapamil (Calan SR, Verelan), Nitrates, such as nitroglycerin (Nitrostat, Nitro-Dur, others) and isosorbide (Isordil, Bidil), Statins, such as atorvastatin (Lipitor), lovastatin (Altoprev) and rosuvastatin (Crestor), Anti-rejection medicine, also called immunosuppressant medicine, such as cyclosporine (Gengraf, Neoral, Sandimmune). If you notice other effects not listed above, contact your doctor or pharmacist. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). McGraw Hill; 2022. https://accessmedicine.mhmedical.com/search. Take them to your local pharmacy which will dispose of them for you. Ask your doctor before using aspirin together with alcohol. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. And as many as 25% of people also take medicines ordered for them by their health care providers, also called prescription medicines. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. My cardiologist recommended I get on metropolol. This is called a medicine interaction. We study 23,548 Isosorbide mononitrate users. Do not stop taking it without consulting your doctor. . Longer-acting tablets and capsules are taken once daily in the morning. Never give it to other people even if their condition appears to be the same as yours. Isosorbide mononitrate is used to prevent chest pain (angina) in patients with a certain heart condition (coronary artery disease). Who should not take Isosorbide Mononitrate? government site. Selected from data included with permission and copyrighted by First Databank, Inc. The https:// ensures that you are connecting to the Integrative medicine (complementary and alternative medicine). It took me a few weeks to adapt to it, but the effect on preventing chest pain was dramatic. Limit alcoholic beverages. Ginkgo. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks ( chest pain ). Review/update the Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. All rights reserved. Isosorbide mononitrate (Monoket) can cause your blood pressure to drop somewhat. 8.0 out of 10 from a total of WebMD does not provide medical advice, diagnosis or treatment. information is beneficial, we may combine your email and website usage information with As precautionary measure, it is preferable to avoid the use of isosorbide mononitrate during pregnancy. This is not a complete list of possible side effects. This content does not have an Arabic version. If tolerance is suspected during the use of transdermal patches they should be left off for 8-12 hours (usually overnight) in each 24 hours; in the case of modified-release tablets of isosorbide dinitrate (and . All rights reserved. This should pass after a few days. Erectile dysfunction medications (e.g., sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)) cannot be taken while you're taking isosorbide mononitrate (Monoket). Methods: Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed. All rights reserved. This content does not have an English version. Yet significantly fewer patients had headache on low dosage than on high dosage (45 vs 57, P < 0.02). Epub 2006 Mar 22. Laboratory and/or medical tests (such as blood pressure) should be performed periodically to monitor your progress or check for side effects. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: continuing ringing or buzzing or other unexplained noise in the ears, dull ache or feeling of pressure or heaviness in the legs, excess air or gas in the stomach or intestines, increased sensitivity of the eyes to sunlight, loss in sexual ability, desire, drive, or performance, pain or tenderness around the eyes and cheekbones, redness of the face, neck, arms, and occasionally, upper chest, redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid, redness, swelling, or soreness of the tongue, small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope, stomach bloating, burning, cramping, or pain, terrifying dreams causing sleep disturbances, uncontrolled twisting movements of the neck, white patches in the mouth, tongue, or throat. Federal government websites often end in .gov or .mil. The IR version can help treat and prevent angina. What happens if I stop taking isosorbide mononitrate (Monoket)? You can develop a tolerance to isosorbide mononitrate (Monoket) over time, which means the dose you've been taking doesn't work as well. Cao HY, Wu HD, Song ZK, Tang ML, Yang S, Liu Y, Qin L. Pan Afr Med J. Never take extra doses or stop taking it suddenly unless your provider tells you to do so. Isosorbide mononitrate belongs to the group of medicines called nitrates. It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. MeSH https://www.uptodate.com/contents/search. Good at preventing chest pain caused by heart disease, Available as a generic version, making it less expensive, Long-acting version only needs to be taken once daily, Short-acting tablets have to be taken on a very specific schedule for the medication to work best. Moderately clinically significant. No you may not. If you have recently had a head injury or a heart attack. View interaction reports for isosorbide mononitrate and the medicines listed below. Coenzyme Q-10 Natural Medicines. Higher dosages are associated with stomach irritation and 2023 eHealthMe.com. eCollection 2021. 46 ratings on Drugs.com. Is it safe to drive while on this medicine? Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). Angina pain develops if part of your heart muscle does not get as much blood and oxygen as it needs. Patients were randomized to either 60 mg 5-ISMN once daily (od) for two weeks or . 19 are major, 174 are moderate, and 2 are minor. This medicine is a white, round, scored, tablet imprinted with "KU 107" and "20". It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. If you have any questions about this medicine ask your pharmacist. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking isosorbide. B12 and folic acid is essential along with iron. Also, it is not intended to be taken just before physical activities (such as exercise or sexual intercourse) to prevent chest pain. Natural Medicines. Alcohol, including beer, wine, and spirits, does raise your blood pressure if its consumed in excess. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The tablet usually is taken two or three times daily. Changing positions slowly can help lessen dizziness. While both isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat) are both nitrate vasodilators, they are not the same medication. Consult your doctor before breast-feeding. http://www.upandaway.org. You may report side effects to the FDA at 1-800-FDA-1088. Isosorbide dinitrate (Isordil) is available as both a short-acting tablet and long-acting capsule. Hawthorn. Isosorbide mononitrate (Monoket) can cause headaches, dizziness, or lightheadedness. Background: If you are having an operation or dental treatment, please remember to tell the person carrying out the treatment which medicines you are taking. Imdur (isosorbide mononitrate) Extended Release and Isordil (isosorbide dinitrate) are vasodilators indicated for the prevention of angina pectoris due to coronary artery disease.. Side effects of Imdur and Isordil that are similar include headache and dizziness.. Side effects of Isordil that are different from Imdur include weakness and skin changes such as redness, tingling, or warmth. Isosorbide mononitrate Alternatives Compared Isosorbide mononitrate Aspirin Nitroglycerin Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. It is used to treat and prevent a wide range of different conditions. Danshen can interact strongly with some heart medicines, such as: Evening primrose may raise your risk of bleeding if you also take a blood thinner, such as: Garlic may raise your risk of bleeding if you also take a blood thinner, such as: Ginkgo biloba may raise your risk of bleeding if you also take a blood thinner, such as: If you take ginseng with warfarin, it may lessen how well warfarin works. It can cause your blood pressure to become dangerously low. 2005 - 2023 WebMD LLC. It can make you really dizzy. isosorbide mononitrate (Rx) Brand and Other Names: Imdur, Monoket, more. It also may keep some medicines from working as well as they should, such as: If your health care provider tells you it's OK to use an herbal supplement along with medicine, be careful. Accessed Sept. 7, 2022. Drug information provided by: IBM Micromedex. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). This is called tolerance, and it cannot be fixed by raising the dose of the medication. May also be prescribed off label for Esophageal Spasm. It is particularly important that you tell your doctor if you are using any medicines to help treat erectile dysfunction. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Upgrade to Patient Pro Medical Professional? tell your doctor and pharmacist if you are allergic to isosorbide; nitroglycerin tablets, patches, or ointment; any other medications, or any of the ingredients in isosorbide tablets, extended-release tablets, or extended-release capsules. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. If it is within 2 hours of the next dose, skip the missed dose. Medicines containing Isosorbide Mononitrate. Headache and weakness of left side (both arm and leg) may suggest a brain pathology. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Alternative cancer treatments: 11 options to consider. The extended-release capsule usually is taken once daily. I strongly feel that there is coronary ischemia. 67% of reviewers reported a positive effect, while 13% reported a negative effect. All rights reserved. Try our Symptom Checker Got any other symptoms? Prescription and OTC Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Isosorbide mononitrate 30% immediate-release 70% sustained-release formulation: a review. The herb licorice may lower warfarin levels and can add to digoxin's effects. you should know that isosorbide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, or at any time, especially if you have been drinking alcoholic beverages. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Continue to take isosorbide even if you feel well. My blood pressure, cholesterol and pulse are all normal and I have no chest pains, shortness of breath or other heart problem symptoms. Always consult your healthcare provider. Accessed Sept. 7, 2022. Registered in England and Wales. Can isosorbide mononitrate cause problems? If you have an eye condition called glaucoma. See also: aspirin side effects in more detail. Some don't work well with prescription medicines. Do not stop taking isosorbide without talking to your doctor. (1) Starting on a low dosage was associated with a reduced frequency and severity of headache and did not notably influence the beneficial effect on angina pectoris. It works to relax your blood vessels. Advertising revenue supports our not-for-profit mission. So get a ct scan brain apart from cardiology workup. Isosorbide mononitrate is used to prevent chest pain in patients with a certain heart condition (coronary artery disease).This medication belongs to a class of drugs known as nitrates. Duplication for commercial use must be authorized by ASHP. Limited data from animal studies indicate no adverse effects on the pregnancy or the unborn child. Do not change the dosing times unless directed by your doctor. Daily headaches are a common side effect. 2021 May 11;39:28. doi: 10.11604/pamj.2021.39.28.22180. [2] It is taken by mouth. https://naturalmedicines.therapeuticresearch.com. It is important to take the drug at the same times each day. Isosorbide mononitrate helps to prevent angina chest pain from developing. Accessibility If concomitant therapy cannot be avoided, monitor clinical effects of the . Ask your pharmacist any questions you have about refilling your prescription. Nitrates, although important for the management of angina pectoris, cause significant headache in many patients. The effects of this exposure on a nursing infant are unknown. You may report side effects to Health Canada at 1-866-234-2345. [2] Your doctor may decide not to treat you with this medication or change some of the other medicines you take.AvanafilRiociguatSildenafilTadalafilVardenafil. Highly clinically significant. Headache is often a sign that this medication is working. Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. This medication belongs to a class of drugs known as nitrates. Natural Medicines. Change positions slowly until your body is used to the medication. Higher than recommend dosage of sublingual isosorbide dinitrate for treating angina pectoris: a case report and review of the literature. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. isosorbide mononitrate, along with The two dosage regimens were equally efficient for the relief of angina pectoris without development of tolerance. Glyceryl trinitrate (GTN) is commonly prescribed for this. This makes it easier for your heart to pump, relieving heart-related chest pain. Even if the medication is working, you may experience some unwanted side effects. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Do not let anyone else take your medication. Take isosorbide exactly as directed. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. Manufacturer's PIL, Imdur 60 mg tablets; TopRidge Pharma Ltd, The electronic Medicines Compendium. Isosorbide mononitrate (Monoket) is not a medication you take if you think you are having a heart attack. There are 7 disease interactions with isosorbide mononitrate which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Ask your pharmacist for a list of the ingredients.